IL-21 is required for the maintenance and pathogenesis of murine Vγ4⁺ IL-17-producing γδT cells.

ABSTRACT: Murine IL-17-producing γδT (γδT17) cells are divided into two subsets: natural γδT17 (nγδT17) cells, whose development is restricted to the fetal thymus, and inducible γδT17 cells, which require antigen exposure for their IL-17 production and are presumed to develop from Rorc ⁺ Il17a ^- CCR9 ⁺ immature γδT17 cells in the adult thymus and whose T cell receptor (TCR) is biased toward Vγ4. Although IL-23 is known to be involved in developing γδT17 cells, the roles of other cytokines, such as IL-21, which is involved in developing Th17 cells like IL-23, in the development, maintenance, and pathophysiology of γδT17 cells remain unknown. Here, we show that IL-21 is dispensable for the fetal thymic development of nγδT17 cells but is required fo

SUBMITTER: Ishikawa J 

PROVIDER: S-EPMC10473412 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature