Association between Change in the peripheral biomarkers of inflammation, astrocyte activation, and neuroprotection at one week of critical illness and hospital mortality in patients with delirium: A prospective cohort study.

ABSTRACT:

Objective

In critically ill adults with delirium, biomarkers of systemic inflammation, astrocyte activation, neuroprotection, and systemic inflammation measured at one week of critical illness may be associated with mortality.

Design

Prospective observational study.

Setting

Intensive care unit (ICU).

Patients

178 ICU patients with delirium, alive and remaining in ICU at one week.

Interventions

None.

Measurements and main results

Blood samples collected for a pair of previously published, negative, clinical trials were utilized. Samples were collected at study enrollment/ICU admission (Day 1 sample) and one week later (Day 8 sample), and analyzed for interleukins (IL)-6, 8, 10, Insulin-like Growth Factor (IGF), S100 Binding Protein (S100B), Tumor N

SUBMITTER: Khan SH 

PROVIDER: S-EPMC10473496 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature