The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy.

ABSTRACT: Endometrial function is dependent on a tight crosstalk between the epithelial and stromal cells of the endometrium. This communication is critical to ensure a fertile uterus and relies on progesterone and estrogen signaling to prepare a receptive uterus for embryo implantation in early pregnancy. One of the key mediators of this crosstalk is the orphan nuclear receptor NR2F2, which regulates uterine epithelial receptivity and stromal cell differentiation. In order to determine the molecular mechanism regulated by NR2F2, RNAseq analysis was conducted on the uterus of Pgr^Cre;Nr2f2^f/f mice at Day 3.5 of pregnancy. This transcriptomic analysis demonstrated Nr2f2 ablation in Pgr-expressing cells leads to a reduction of Hand2 expression, increase

SUBMITTER: Oh Y 

PROVIDER: S-EPMC10473531 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature