Mendelian randomization study shows a causal effect of asthma on chronic obstructive pulmonary disease risk.

ABSTRACT:

Background

This study was performed to explore the causal association between asthma and chronic obstructive pulmonary disease(COPD).

Methods

We obtained summary statistics for asthma from 408,442 Europeans in an open genome-wide association study (GWAS) from the UK Biobank to select strongly associated single nucleotide polymorphisms that could serve as instrumental variables for asthma (P < 5×10-8). Additional summary statistics for COPD were obtained from 193,638 individuals of European ancestry in the GWAS published by FinnGen. Univariable Mendelian randomization(UVMR) analysis was performed using inverse variance weighted (IVW) as the primary method of analysis. The reliability of the results was verified by multivariable MR(MVMR), reverse and replication MR analysis, a

SUBMITTER: Li Y 

PROVIDER: S-EPMC10473539 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature