Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study

ABSTRACT:

Background

Based on epidemiological reports, severe mental illness (SMI) and breast cancer (BC) risk are linked positively. However, it is susceptible to clinical confounding factors, such as smoking, alcohol consumption, etc. Here, we performed a two-sample, two-step multivariable Mendelian randomization (MR) research to explore how the SMI etiologically influences BC risk and to quantify mediating effects of known modifiable risk factors.

Methods

Data concerning the single nucleotide polymorphism (SNP)-associated with schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), and BC were obtained from two large consortia: the Breast Cancer Association Consortium (BCAC) and the Psychiatric Genomics Consortium (PGC). Then, the correlations of the previous SMI

SUBMITTER: Cui Y 

PROVIDER: S-EPMC10473543 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature