Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease.

ABSTRACT: The critical role of alpha-synuclein in Parkinson's disease represents a pivotal discovery. Some progress has been made over recent years in identifying disease-modifying therapies for Parkinson's disease that target alpha-synuclein. However, these treatments have not yet shown clear efficacy in slowing the progression of this disease. Several explanations exist for this issue. The pathogenesis of Parkinson's disease is complex and not yet fully clarified and the heterogeneity of the disease, with diverse genetic susceptibility and risk factors and different clinical courses, adds further complexity. Thus, a deep understanding of alpha-synuclein physiological and pathophysiological functions is crucial. In this review, we first describe the cellular and animal models developed over recent

SUBMITTER: Calabresi P 

PROVIDER: S-EPMC10473562 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature