Genetically identical twin-pair difference models support the amyloid cascade hypothesis.

ABSTRACT: The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research agenda and clinical trial designs over the past decades, but precisely how amyloid-β pathology initiates the aggregation of neocortical tau remains unclear. We cannot exclude the possibility of a shared upstream process driving both amyloid-β and tau in an independent manner instead of there being a causal relationship between amyloid-β and tau. Here, we tested the premise that if a causal relationship exists, then exposure should be associated with outcome both at the individual level as well as within identical twin-pairs, who are strongly matched on genetic, demographic and shared environmental background. Specifically, we tested associations between longitudinal amyloid-β PET and cross-sectional tau P

SUBMITTER: Coomans EM 

PROVIDER: S-EPMC10473566 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature