Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy.

ABSTRACT: Neurosurgical intervention is the best available treatment for selected patients with drug resistant epilepsy. For these patients, surgical planning requires biomarkers that delineate the epileptogenic zone, the brain area that is indispensable for the generation of seizures. Interictal spikes recorded with electrophysiological techniques are considered key biomarkers of epilepsy. Yet, they lack specificity, mostly because they propagate across brain areas forming networks. Understanding the relationship between interictal spike propagation and functional connections among the involved brain areas may help develop novel biomarkers that can delineate the epileptogenic zone with high precision. Here, we reveal the relationship between spike propagation and effective connectivity among onset

SUBMITTER: Matarrese MAG 

PROVIDER: S-EPMC10473571 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature