Impulse control disorder in Parkinson's disease is associated with abnormal frontal value signalling.

ABSTRACT: Dopaminergic medication is well established to boost reward- versus punishment-based learning in Parkinson's disease. However, there is tremendous variability in dopaminergic medication effects across different individuals, with some patients exhibiting much greater cognitive sensitivity to medication than others. We aimed to unravel the mechanisms underlying this individual variability in a large heterogeneous sample of early-stage patients with Parkinson's disease as a function of comorbid neuropsychiatric symptomatology, in particular impulse control disorders and depression. One hundred and ninety-nine patients with Parkinson's disease (138 ON medication and 61 OFF medication) and 59 healthy controls were scanned with functional MRI while they performed an established probabilistic ins

SUBMITTER: Tichelaar JG 

PROVIDER: S-EPMC10473575 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature