Disrupted excitation-inhibition balance in cognitively normal individuals at risk of Alzheimer's disease.

ABSTRACT:

Background

Sex differences impact Alzheimer's disease (AD) neuropathology, but cell-to-network level dysfunctions in the prodromal phase are unclear. Alterations in hippocampal excitation-inhibition balance (EIB) have recently been linked to early AD pathology.

Objective

Examine how AD risk factors (age, APOE-ɛ4, amyloid-β) relate to hippocampal EIB in cognitively normal males and females using connectome-level measures.

Methods

Individuals from the OASIS-3 cohort (age 42-95) were studied (N = 437), with a subset aged 65+ undergoing neuropsychological testing (N = 231).

Results

In absence of AD risk factors (APOE-ɛ4/Aβ+), whole-brain EIB decreases with age more significantly in males than females (p = 0.021, β = -0.007). Regression modeling including APOE-ɛ4 al

SUBMITTER: Fortel I 

PROVIDER: S-EPMC10473582 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature