Long-term history dependence of growth rates of E. coli after nutrient shifts.

ABSTRACT: According to a widely accepted paradigm of microbiology, steady-state growth rates are determined solely by current growth conditions ^1-3 and adaptations between growth states are rapid, as recently recapitulated by simple resource allocation models ⁴ . However, even in microbes overlapping regulatory networks can yield multi-stability or long-term cellular memory. Species like Listeria monocytogenes ⁵ and Bacillus subtilis "distinguish" distinct histories for the commitment to sporulation ⁶ , but it is unclear if these states can persist over many generations. Remarkably, studying carbon co-utilization of Escherichia coli , we found that growth rates on combinations of carbon sources can depend critically on the previous gro

SUBMITTER: Christodoulou D 

PROVIDER: S-EPMC10473606 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature