Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms.

ABSTRACT: Magnesium ions (Mg²⁺) play an essential role in cellular physiology. In mitochondria, protein and ATP synthesis and various metabolic pathways are directly regulated by Mg²⁺. MRS2, a magnesium channel located in the inner mitochondrial membrane, mediates the influx of Mg²⁺ into the mitochondrial matrix and regulates Mg²⁺ homeostasis. Knockdown of MRS2 in human cells leads to reduced uptake of Mg²⁺ into mitochondria and disruption of the mitochondrial metabolism. Despite the importance of MRS2, the Mg²⁺ translocation and regulation mechanisms of MRS2 are still unclear. Here, using cryo-EM we determined the structure of human MRS2 in the presence and absence of Mg²⁺ at 2.8 Å and 3.3 Å, respectively. From the homo-pe

SUBMITTER: Lai LTF 

PROVIDER: S-EPMC10473633 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature