A suppressor screen in C. elegans identifies a multi-protein interaction interface that stabilizes the synaptonemal complex.

ABSTRACT: Successful chromosome segregation into gametes depends on tightly-regulated interactions between the parental chromosomes. During meiosis, chromosomes are aligned end-to-end by an interface called the synaptonemal complex, which also regulates exchanges between them. However, despite the functional and ultrastructural conservation of this essential interface, how protein-protein interactions within the synaptonemal complex regulate chromosomal interactions remains poorly understood. Here we describe a novel interaction interface in the C. elegans synaptonemal complex, comprised of short segments of three proteins, SYP-1, SYP-3 and SYP-4. We identified the interface through a saturated suppressor screen of a mutant that destabilizes the synaptonemal complex. The specificity and tight

SUBMITTER: Kursel LE 

PROVIDER: S-EPMC10473659 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature