Niche-specific macrophage loss promotes skin capillary aging.

ABSTRACT: All mammalian organs depend upon resident macrophage populations to coordinate repair processes and facilitate tissue-specific functions^1-3. Recent work has established that functionally distinct macrophage populations reside in discrete tissue niches and are replenished through some combination of local proliferation and monocyte recruitment^4,5. Moreover, decline in macrophage abundance and function in tissues has been shown to contribute to many age-associated pathologies, such as atherosclerosis, cancer, and neurodegeneration^6-8. Despite these advances, the cellular mechanisms that coordinate macrophage organization and replenishment within an aging tissue niche remain largely unknown. Here we show that capillary-associated macrophages (CAMs) are selecti

SUBMITTER: Mesa KR 

PROVIDER: S-EPMC10473701 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature