Cell Fate Programming by Transcription Factors and Epigenetic Machinery in Stomatal Development.

ABSTRACT: The development of multi-cellular organisms requires coordinated changes in gene expression that are often mediated by the interaction between transcription factors (TFs) and their corresponding cis-regulatory elements (CREs). During development and differentiation, the accessibility of CREs is dynamically modulated by the epigenome. How the epigenome, CREs and TFs together exert control over cell fate commitment remains to be fully understood. In the Arabidopsis leaf epidermis, meristemoids undergo a series of stereotyped cell divisions, then switch fate to commit to stomatal differentiation. Newly created or reanalyzed scRNA-seq and ChIP-seq data confirm that stomatal development involves distinctive phases of transcriptional regulation and that differentially regulated genes are

SUBMITTER: Liu A 

PROVIDER: S-EPMC10473704 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature