Cytoskeletal adaptation following long-term dysregulation of actomyosin in neuronal processes.

ABSTRACT: Microtubules, intermediate filaments, and actin are cytoskeletal polymer networks found within the cell. While each has unique functions, all the cytoskeletal elements must work together for cellular mechanics to be fully operative. This is achieved through crosstalk mechanisms whereby the different networks influence each other through signaling pathways and direct interactions. Because crosstalk can be complex, it is possible for perturbations in one cytoskeletal element to affect the others in ways that are difficult to predict. Here we investigated how long-term changes to the actin cytoskeleton affect microtubules and intermediate filaments. Reducing F-actin or actomyosin contractility increased acetylated microtubules and intermediate filament expression, with the effect being signif

SUBMITTER: Cisterna BA 

PROVIDER: S-EPMC10473725 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature