Specialized structure of neural population codes in parietal cortex outputs.

ABSTRACT: Do cortical neurons that send axonal projections to the same target area form specialized population codes for transmitting information? We used calcium imaging in mouse posterior parietal cortex (PPC), retrograde labeling, and statistical multivariate models to address this question during a delayed match-to-sample task. We found that PPC broadcasts sensory, choice, and locomotion signals widely, but sensory information is enriched in the output to anterior cingulate cortex. Neurons projecting to the same area have elevated pairwise activity correlations. These correlations are structured as information-limiting and information-enhancing interaction networks that collectively enhance information levels. This network structure is unique to sub-populations projecting to the same target and

SUBMITTER: Safaai H 

PROVIDER: S-EPMC10473762 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature