Comparative neuroimaging of sex differences in human and mouse brain anatomy.

ABSTRACT: In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but the causes of such differences are hard to parse. While mouse models are useful for understanding the cellular and mechanistic bases of sex-biased brain development in mammals, there have been no attempts to formally compare mouse and human sex differences across the whole brain to ascertain how well they translate. Addressing this question would shed critical light on use of the mouse as a translational model for sex differences in the human brain and provide insights into the degree to which sex differences in brain volume are conserved across mammals. Here, we use cross-species structural magnetic resonance imaging to carry out the first comparative neuroimaging study of

SUBMITTER: Guma E 

PROVIDER: S-EPMC10473765 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature