Uncovering Spatiotemporal Dynamics of the Corticothalamic Network during Seizures.

ABSTRACT:

Objective

Although the clinical efficacy of deep brain stimulation targeting the anterior nucleus (AN) and centromedian nucleus (CM) of the thalamus has been actively investigated for the treatment of medication-resistant epilepsy, few studies have investigated dynamic ictal changes in corticothalamic connectivity in human EEG recording. This study aims to establish the complex spatiotemporal dynamics of the ictal corticothalamic network associated with various seizure foci.

Methods

We analyzed ten patients (aged 2.7-28.1) with medication-resistant focal epilepsy who underwent stereotactic EEG evaluation with thalamic coverage. We examined both undirected and directed connectivity, incorporating coherence and spectral Granger causality analysis (GCA) between the diverse seiz

SUBMITTER: Panchavati S 

PROVIDER: S-EPMC10473800 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature