Lysophosphatidylcholines are associated with P-tau181 levels in early stages of Alzheimer's Disease.

ABSTRACT:

Background

We investigated systemic biochemical changes in Alzheimer's disease (AD) by investigating the relationship between circulating plasma metabolites and both clinical and biomarker-assisted diagnosis of AD.

Methods

We used an untargeted approach with liquid chromatography coupled to high-resolution mass spectrometry to measure exogenous and endogenous small molecule metabolites in plasma from 150 individuals clinically diagnosed with AD and 567 age-matched elderly without dementia of Caribbean Hispanic ancestry. Plasma biomarkers of AD were also measured including P-tau181, Aβ40, Aβ42, total tau, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP). Association of individual and co-expressed modules of metabolites were tested with the clinical d

SUBMITTER: Kalia V 

PROVIDER: S-EPMC10473810 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature