Evolution of Human Brain Left-Right Asymmetry: Old Genes with New Functions.

ABSTRACT: The human brain is generally anatomically symmetrical, boasting mirror-like brain regions in the left and right hemispheres. Despite this symmetry, fine-scale structural asymmetries are prevalent and are believed to be responsible for distinct functional divisions within the brain. Prior studies propose that these asymmetric structures are predominantly primate specific or even unique to humans, suggesting that the genes contributing to the structural asymmetry of the human brain might have evolved recently. In our study, we identified approximately 1,500 traits associated with human brain asymmetry by collecting paired brain magnetic resonance imaging features from the UK Biobank. Each trait is measured in a specific region of one hemisphere and mirrored in the corresponding region of the

SUBMITTER: Wang J 

PROVIDER: S-EPMC10473864 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature