CD1b glycoprotein, a crucial marker of thymocyte development during T cell maturation in cynomolgus monkeys.

ABSTRACT: Phenotypic markers that denote different developmental stages of thymocytes are important for understanding T cell development in the thymus. Here, we show that CD1b is a critical discriminator of thymocyte maturation stage in cynomolgus monkeys. CD1b was expressed by immature thymocytes prior to β-selection, and its expression decreased as cells became fully mature in the thymus. MHC-I expression was lowest at the CD3^loCD1b⁺ immature double-positive (DP) stage, while the ratio of CD1d:MHC-I expression was significantly higher at this stage than at other developmental stages. PLZF was expressed by < 0.2% of thymocytes; most PLZF⁺ thymocytes were CD3^-/loCD1b⁺ immature DP thymocytes with the potential to produce IL-4. EOMES⁺ t

SUBMITTER: Choi SM 

PROVIDER: S-EPMC10474046 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature