Morphometric similarity network alterations in COVID-19 survivors correlate with behavioral features and transcriptional signatures

ABSTRACT: Highlights • COVID-19 survivors exhibited morphometric similarity network (MSN) alterations in several regions.• Regional MSN values were associated with GAD-7 and PHQ-9 scores in COVID-19 survivors.• Analysis of spatial similarities showed that seven risk genes were related to regional MSN values.

Objectives

To explore the differences in the cortical morphometric similarity network (MSN) between COVID-19 survivors and healthy controls, and the correlation between these differences and behavioral features and transcriptional signatures.

Materials & methods

39 COVID-19 survivors and 39 age-, sex- and education years-matched healthy controls (HCs) were included. All participants underwent MRI and behavioral assessments (PCL-17, GAD-7, PHQ-9). MSN analysis was used to comput

SUBMITTER: Long J 

PROVIDER: S-EPMC10474075 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature