Proteomic and phosphoproteomic analyses of myectomy tissue reveals difference between sarcomeric and genotype-negative hypertrophic cardiomyopathy.

ABSTRACT: Hypertrophic cardiomyopathy (HCM) is a genetically heterogenous condition with about half of cases remaining genetically elusive or non-genetic in origin. HCM patients with a positive genetic test (HCM_Sarc) present earlier and with more severe disease than those with a negative genetic test (HCM_Neg). We hypothesized these differences may be due to and/or reflect proteomic and phosphoproteomic differences between the two groups. TMT-labeled mass spectrometry was performed on 15 HCM_Sarc, 8 HCM_Neg, and 7 control samples. There were 243 proteins differentially expressed and 257 proteins differentially phosphorylated between HCM_Sarc and HCM_Neg. About 90% of pathways altered between genotypes were in disease-related pathways and H

SUBMITTER: Garmany R 

PROVIDER: S-EPMC10474105 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature