Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans.

ABSTRACT: Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive technique for focally modulating human brain function. The mechanisms and neurochemical substrates underlying TUS neuromodulation in humans and how these relate to excitation and inhibition are still poorly understood. In 24 healthy controls, we separately stimulated two deep cortical regions and investigated the effects of theta-burst TUS, a protocol shown to increase corticospinal excitability, on the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and functional connectivity. We show that theta-burst TUS in humans selectively reduces GABA levels in the posterior cingulate, but not the dorsal anterior cingulate cortex. Functional connectivity increased following TUS in both regions. Our finding

SUBMITTER: Yaakub SN 

PROVIDER: S-EPMC10474159 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature