Vascular risk factors and astrocytic marker for the glymphatic system activity.

ABSTRACT:

Objectives

Glymphatic system maintains brain fluid circulation via active transportation of astrocytic aquaporin-4 in perivascular space. The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is an established method measuring perivascular glymphatic activity, but comprehensive investigations into its influential factors are lacking.

Methods

Community-dwelling older adults underwent brain MRI scans, neuropsychiatric, and multi-domain assessments. Blood biomarker tests included glial fibrillary acidic protein (GFAP) for astrocyte injury.

Results

In 71 enrolled participants, the DTI-ALPS index was associated with modifiable factors, including lipid profile (high-density lipoprotein, r = 0.396; very-low-density lipoprotein, r =  - 0.342), glucose

SUBMITTER: Wei YC 

PROVIDER: S-EPMC10474179 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature