Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes.

ABSTRACT: COVID-19 vaccines have been instrumental tools in the fight against SARS-CoV-2 helping to reduce disease severity and mortality. At the same time, just like any other therapeutic, COVID-19 vaccines were associated with adverse events. Women have reported menstrual cycle irregularity after receiving COVID-19 vaccines, and this led to renewed fears concerning COVID-19 vaccines and their effects on fertility. Herein we devised an informatics workflow to explore the causal drivers of menstrual cycle irregularity in response to vaccination with mRNA COVID-19 vaccine BNT162b2. Our methods relied on gene expression analysis in response to vaccination, followed by network biology analysis to derive testable hypotheses regarding the causal links between BNT162b2 and menstrual cycle irregularity. Fi

SUBMITTER: Hajjo R 

PROVIDER: S-EPMC10474200 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature