Low-density lipoprotein cholesterol, statin therapy, and cerebral microbleeds: The CIRCLE study.

ABSTRACT:

Background

Current evidence suggests a potential association between cerebral microbleeds (CMBs), low-density lipoprotein cholesterol (LDL-C) levels, and statin use, but the exact relationship remains unclear. This study aims to prospectively examine these relationships in a stroke-free population.

Methods

From January 2010 to January 2020, we enrolled stroke-free individuals with at least one cerebral small vessel disease imaging marker from the CIRCLE study (ClinicalTrials.gov ID: NCT03542734). Participants underwent baseline and 1-year follow-up susceptibility-weighted imaging (SWI), and baseline LDL-C testing. New CMBs were categorized as strictly lobar and deep CMBs based on location.

Results

A total of 209 individuals were included. Baseline serum LDL-C levels w

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10474226 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature