Two-sample mendelian randomization reveals a causal association between membranous nephropathy and lung cancer.

ABSTRACT: A risk association between membranous nephropathy (MN) and lung cancer is reported, but traditional observational studies cannot provide strong evidence of its causality. This study aimed to assess genome-wide association studies data for a causal relationship between MN and lung cancer using a two-sample Mendelian randomization (MR) approach. Inverse-variance weighted, and MR Egger regression techniques were used to determine the association of genetic variants from cohorts of MN and lung cancer patients. Independent genetic variants with genome-wide significance (P < 5×10^-8) were used to determine the direction of chance. Sensitivity analyses confirmed the accuracy of the results. The results suggest that MN is an exposure factor for lung cancer, validated using a second cohor

SUBMITTER: Yang K 

PROVIDER: S-EPMC10474265 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature