Statin use and risk of colorectal cancer in patients with inflammatory bowel disease.

ABSTRACT:

Background

Statin use has been linked to a reduced risk of advanced colorectal adenomas, but its association with colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) - a high risk population for CRC - remains inconclusive.

Methods

From a nationwide IBD cohort in Sweden, we identified 5273 statin users and 5273 non-statin users (1:1 propensity score matching) from July 2006 to December 2018. Statin use was defined as the first filled prescription for ≥30 cumulative defined daily doses and followed until December 2019. Primary outcome was incident CRC. Secondary outcomes were CRC-related mortality and all-cause mortality. Cox regression estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).

Findings

During a median follow-up of

SUBMITTER: Sun J 

PROVIDER: S-EPMC10474364 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature