Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria.

ABSTRACT:

Background

Malaria in pregnancy (MIP) causes higher morbidity in primigravid compared to multigravid women; however, the correlates and mechanisms underlying this gravidity-dependent protection remain incompletely understood. We aimed to compare the cellular immune response between primigravid and multigravid women living in a malaria-endemic region and assess for correlates of protection against MIP.

Methods

We characterised the second trimester cellular immune response among 203 primigravid and multigravid pregnant women enrolled in two clinical trials of chemoprevention in eastern Uganda, utilizing RNA sequencing, flow cytometry, and functional assays. We compared responses across gravidity and determined associations with parasitaemia during pregnancy and placental malar

SUBMITTER: Kirosingh AS 

PROVIDER: S-EPMC10474374 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature