Prognostic value of GLCE and infiltrating immune cells in Ewing sarcoma.

ABSTRACT:

Background

The prognostic value of D-glucuronyl C5-epimerase (GLCE) and mast cell infiltration in Ewing sarcoma (ES) has not been well specified and highlighted, which may facilitate survival prediction and treatment.

Methods

Several qualified datasets were downloaded from the GEO website. Common differentially expressed genes between normal subjects and ES patients in GSE17679, GSE45544, and GSE68776 were identified and screened by multiple algorithms to find hub genes with prognostic value. The prognostic value of 64 infiltrating cells was also explored. A prognostic model was established and then validated with GSE63155 and GSE63156. Finally, functional analysis was performed.

Results

GLCE and mast cell infiltration were screened as two indicators for

SUBMITTER: Wen J 

PROVIDER: S-EPMC10474439 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature