Multimodal imaging study of the 5-HT_1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia.

ABSTRACT:

Introduction

The leading treatment for motor signs of Parkinson's disease is L-DOPA, but, upon extended use, it can lead to levodopa-induced dyskinesia (LID). Serotonergic neurons are involved in LID etiology and previous pre-clinical studies have shown that NLX-112, a 5-HT_1A biased agonist, has robust antidyskinetic effects. Here, we investigated its effects in hemiparkinsonian (HPK) rats with a unilateral nigrostriatal 6-OHDA lesion.

Methods

We compared HPK rats with LID (i.e., sensitized to the dyskinetic effects of chronic L-DOPA) and without LID (HPK-non-LID), using [¹⁸F]FDG PET imaging and fMRI functional connectivity following systemic treatment with saline, L-DOPA, NLX-112 or L-DOPA + NLX-112.

Results

In HPK-non-LID rats, [¹⁸F]

SUBMITTER: Chaib S 

PROVIDER: S-EPMC10474496 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature