A Centralized EHR-Based Model for the Recruitment of Rural and Lower Socioeconomic Participants in Pragmatic Trials: A Secondary Analysis of the Diuretic Comparison Project.

ABSTRACT:

Importance

Participant diversity is important for reducing study bias and increasing generalizability of comparative effectiveness research.

Objective

Demonstrate the operational efficiency of a centralized electronic health record (EHR)-based model for recruiting difficult-to-reach participants in a pragmatic trial.

Design, setting, and participants

This comparative effectiveness study was a secondary analysis of Diuretic Comparison Project, a randomized clinical trial conducted between 2016 and 2022 (mean [SD] follow-up, 2.4 [1.4] years) comparing 2 commonly prescribed antihypertensives, which used an EHR-based recruitment model. Electronic study workflows, in tandem with routine clinical practice, were adapted by 72 Veteran Affairs (VA) primary care networks. Data

SUBMITTER: Hau C 

PROVIDER: S-EPMC10474559 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature