Single-cell analysis of human prepuce reveals dynamic changes in gene regulation and cellular communications.

ABSTRACT:

Background

The cellular and molecular dynamics of human prepuce are crucial for understanding its biological and physiological functions, as well as the prevention of related genital diseases. However, the cellular compositions and heterogeneity of human prepuce at single-cell resolution are still largely unknown. Here we systematically dissected the prepuce of children and adults based on the single-cell RNA-seq data of 90,770 qualified cells.

Results

We identified 15 prepuce cell subtypes, including fibroblast, smooth muscle cells, T/natural killer cells, macrophages, vascular endothelial cells, and dendritic cells. The proportions of these cell types varied among different individuals as well as between children and adults. Moreover, we detected cell-type-specific gene re

SUBMITTER: Tan F 

PROVIDER: S-EPMC10474653 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature