Cost-effectiveness analysis of liver transplantation in biliary atresia according to the severity of end-stage liver disease.

ABSTRACT:

Background

Timing for liver transplantation (LT) in biliary atresia (BA) children with end-stage liver disease (ESLD) is associated with all-cause mortality. The cut-off value of pediatric end-stage liver disease (PELD) score for LT consideration varies across institutions. We aimed to determine the cost-effectiveness of LT to prevent death among BA children registered on the waiting list with different severities of ESLD.

Methods

Subjects were BA children aged < 12 years at a transplant center between 2010 and 2021. A decision tree was developed for cost-effectiveness analysis from a hospital perspective to compare all-cause death between patients initially registered with a low PELD score (< 15) and a high PELD score (≥ 15). Each patient's direct medical cost was retrieved

SUBMITTER: Sihaklang B 

PROVIDER: S-EPMC10474723 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature