Polyhydroxylated Fullerene C₆₀(OH)₄₀ Nanofilms Promote the Mesenchymal-Epithelial Transition of Human Liver Cancer Cells via the TGF-β1/Smad Pathway.

ABSTRACT:

Background

The various growth factors change the phenotype of neoplastic cells from sedentary (epithelial) to invasive (mesenchymal), which weaken intercellular connections and promote chemotaxis. It can be assumed that the use of anti-inflammatory polyhydroxyfull nanofilms will restore the sedentary phenotype of neoplastic cells in the primary site of the tumor and, consequently, increase the effectiveness of the therapy.

Methods

The studies were carried out on liver cancer cells HepG2, C3A and SNU-449, and non-cancer hepatic cell line THLE-3. Transforming growth factor (TGF), epidermal growth factor and tumor necrosis factor were used to induce the epithelial-mesenchymal transition. C₆₀(OH)₄₀ nanofilm was used to induce the mesenchymal-epithelial tran

SUBMITTER: Sosnowska M 

PROVIDER: S-EPMC10474868 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature