Iron deficiency in pulmonary vascular disease: pathophysiological and clinical implications.

ABSTRACT:

Aims

Iron deficiency is common in pulmonary hypertension, but its clinical significance and optimal definition remain unclear.

Methods and results

Phenotypic data for 1028 patients enrolled in the Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics study were analyzed. Iron deficiency was defined using the conventional heart failure definition and also based upon optimal cut-points associated with impaired peak oxygen consumption (peakVO2), 6-min walk test distance, and 36-Item Short Form Survey (SF-36) scores. The relationships between iron deficiency and cardiac and pulmonary vascular function and structure and outcomes were assessed. The heart failure definition of iron deficiency endorsed by pulmonary hypertension guidelines did not identify pa

SUBMITTER: Martens P 

PROVIDER: S-EPMC10474927 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature