Somatic mutation effects diffused over microRNA dysregulation.

ABSTRACT:

Motivation

As an important player in transcriptome regulation, microRNAs may effectively diffuse somatic mutation impacts to broad cellular processes and ultimately manifest disease and dictate prognosis. Previous studies that tried to correlate mutation with gene expression dysregulation neglected to adjust for the disparate multitudes of false positives associated with unequal sample sizes and uneven class balancing scenarios.

Results

To properly address this issue, we developed a statistical framework to rigorously assess the extent of mutation impact on microRNAs in relation to a permutation-based null distribution of a matching sample structure. Carrying out the framework in a pan-cancer study, we ascertained 9008 protein-coding genes with statistically significant muta

SUBMITTER: Yu H 

PROVIDER: S-EPMC10474951 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature