Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway.

ABSTRACT: Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove the primary tumor, metastases remain poorly accessible. To overcome this limitation, herein, the development of a theranostic nanomaterial by incorporating a chromophore for imaging and a photosensitizer for treatment of metastatic tumor sites is presented. The mechanism of action reveals that the nanoparticles are able to intervene by local generation of cellular damage through photodynamic therapy as well as by systemic induction of an immune response by immunotherapy upon inhibition of the mTOR signaling pathway which is of crucial importance for tumor onset, progression and metastatic spreading. The nanomaterial is able to strongly reduce

SUBMITTER: Zhou H 

PROVIDER: S-EPMC10475087 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature