Deciphering migraine pain mechanisms through electrophysiological insights of trigeminal ganglion neurons.

ABSTRACT: Migraine is a complex neurological disorder that affects millions of people worldwide. Despite extensive research, the underlying mechanisms that drive migraine pain and related abnormal sensation symptoms, such as hyperalgesia, allodynia, hyperesthesia, and paresthesia, remain poorly understood. One of the proposed mechanisms is cortical spreading depression (CSD), which is believed to be involved in the regulation of trigeminovascular pathways by sensitizing the pain pathway. Another mechanism is serotonin depletion, which is implicated in many neurological disorders and has been shown to exacerbate CSD-evoked pain at the cortical level. However, the effects of CSD and serotonin depletion on trigeminal ganglion neurons, which play a critical role in pain signal transmission, have not bee

SUBMITTER: Vongseenin S 

PROVIDER: S-EPMC10475091 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature