Thermal neuromodulation using pulsed and continuous infrared illumination in a penicillin-induced acute epilepsy model.

ABSTRACT: Infrared neuromodulation (INM) is a promising neuromodulation tool that utilizes pulsed or continuous-wave near-infrared (NIR) laser light to produce an elevation of the background temperature of the neural tissue. The INM-based cortical heating has been proven as an effective modality to induce changes in neuronal activities. In this paper, we investigate the effect of INM-based cortical heating on the characteristics of interictal epileptiform discharges (IEDs) induced by penicillin in anesthetized rats. Cortical heating was conducted using a NIR laser light guided through a needle-like silicon-based waveguide probe. We detected penicillin-induced cortical IEDs from preprocessed micro-electrocorticography ([Formula: see text]ECoG) recordings, then we assessed changes in various temporal

SUBMITTER: Ismaiel E 

PROVIDER: S-EPMC10475096 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature