Improving measurement of blood-brain barrier permeability with reduced scan time using deep-learning-derived capillary input function.

ABSTRACT:

Purpose

In Dynamic contrast-enhanced MRI (DCE-MRI), Arterial Input Function (AIF) has been shown to be a significant contributor to uncertainty in the estimation of kinetic parameters. This study is to assess the feasibility of using a deep learning network to estimate local Capillary Input Function (CIF) to estimate blood-brain barrier (BBB) permeability, while reducing the required scan time.

Materials and method

A total of 13 healthy subjects (younger (<40 y/o): 8, older (> 67 y/o): 5) were recruited and underwent 25-min DCE-MRI scans. The 25 min data were retrospectively truncated to 10 min to simulate a reduced scan time of 10 min. A deep learning network was trained to predict the CIF using simulated tissue contrast dynamics with two vascular transport models. The BBB

SUBMITTER: Bae J 

PROVIDER: S-EPMC10475161 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature