Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization study.

ABSTRACT:

Background

The presence of type 1 diabetes mellitus (T1DM) has been demonstrated to pose an increased risk for developing cardiovascular diseases (CVDs). However, the causal relationships between T1DM and CVDs remain unclear due to the uncontrolled confounding factors and reverse causation bias of the observational studies.

Methods

Summary statistics of T1DM and seven CVDs from the largest available genome-wide association studies (GWAS) of European ancestry and FinnGen biobank were extracted for the primary MR analysis, and the analysis was replicated using UK biobank (UKBB) for validation. Three complementary methods: inverse variance weighted (IVW), weighted median, and MR-Egger were used for the MR estimates. The potential pleiotropic effects were assessed by MR-Egger in

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10475187 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature