Zyxin inhibits the epithelial-mesenchymal transition process in gastric cancer by upregulating SIRT1.

ABSTRACT: Tumor development relies on the stemness of cancer stem cells, which is regulated by environmental cues. Previous studies have shown that zyxin can inhibit the expression of genes for embryonic stem cell status. In the present study, the expression levels of zyxin protein in cancer tissues and adjacent noncancerous tissues from 73 gastric cancer patients with different clinical stages were analyzed by Western blot. We showed that the relative expression levels of zyxin in gastric cancer tissues (cancer tissues/adjacent tissues) were significantly downregulated in advanced clinical stages. Overexpression of zyxin inhibited the stemness and epithelial-mesenchymal transition (EMT) processes in gastric cancer cells. Zyxin also inhibited the proliferation, migration, and invasion but increased

SUBMITTER: Lou J 

PROVIDER: S-EPMC10475219 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature