Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice.

ABSTRACT:

Aims

There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the risk of hypertension by combined human epidemiological and mouse experimental studies.

Methods and results

This study focused on the total arsenic level in fasting serum, a biomarker of arsenic exposure. Associations among ingestion frequencies of 54 diet items of Japanese food separated into six categories, total arsenic level in fasting serum, and the prevalence of hypertension were investigated in 2709 general people in Japan. Logistic regression analysis demonstrated a dose-dependent association between serum arsenic level and

SUBMITTER: Kagawa T 

PROVIDER: S-EPMC10475452 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature