Electroacupuncture attenuates myocardial ischemia-reperfusion injury by inhibiting microglial engulfment of dendritic spines.

ABSTRACT: A major side effect of reperfusion therapy following myocardial infarction is myocardial ischemia-reperfusion injury (MIRI). Electroacupuncture preconditioning (EA-pre) has a long history in the treatment of cardiovascular diseases. Here, we demonstrate how EA-pre attenuates MIRI by affecting the phagocytosis of neuronal dendritic spines of microglia of the fastigial nucleus (FN^microglia). We observed that EA-pre increased activity in FN^GABA and then improved myocardial injury by inhibiting abnormal activities of glutaminergic neurons of the FN (FN^Glu) during MIRI. Interestingly, we observed changes in the quantity and shape of FN microglia in mice treated with EA-pre and a decrease in the phagocytosis of FN^GABA neuronal dendritic spines by micro

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10475514 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature