Abnormal static and dynamic functional network connectivity of the whole-brain in children with generalized tonic-clonic seizures

ABSTRACT:

Introduction

Generalized tonic-clonic seizures (GTCS) are a subtype of generalized seizures exhibiting bursts of bilaterally synchronous generalized spike-wave discharges. Numerous neuroimaging studies have reported aberrant functional activity and topological organization of brain network in epilepsy patients with GTCS, but most studies have focused on adults. However, the effect of GTCS on the spatial and temporal properties of brain function in children remains unclear. The present study aimed to explore whole-brain static (sFC) and dynamic functional connectivity (dFC) in children with GTCS.

Methods

Twenty-three children with GTCS and 32 matched healthy controls (HCs) were recruited for the present study. Resting-state functional magnetic resonance imaging (MRI) data

SUBMITTER: Li Y 

PROVIDER: S-EPMC10475552 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature