CD5 Expression Dynamically Changes During the Differentiation of Human CD8⁺ T Cells Predicting Clinical Response to Immunotherapy.

ABSTRACT: Defining the molecular dynamics associated with T cell differentiation enhances our understanding of T cell biology and opens up new possibilities for clinical implications. In this study, we investigated the dynamics of CD5 expression in CD8⁺ T cell differentiation and explored its potential clinical uses. Using PBMCs from 29 healthy donors, we observed a stepwise decrease in CD5 expression as CD8⁺ T cells progressed through the differentiation stages. Interestingly, we found that CD5 expression was initially upregulated in response to T cell receptor stimulation, but diminished as the cells underwent proliferation, potentially explaining the differentiation-associated CD5 downregulation. Based on the proliferation-dependent downregulation of CD5, we hypothesized tha

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC10475823 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature