Optical absorption spectra and corresponding in vivo photoacoustic visualization of exposed peripheral nerves.

ABSTRACT:

Significance

Multispectral photoacoustic imaging has the potential to identify lipid-rich, myelinated nerve tissue in an interventional or surgical setting (e.g., to guide intraoperative decisions when exposing a nerve during reconstructive surgery by limiting operations to nerves needing repair, with no impact to healthy or regenerating nerves). Lipids have two optical absorption peaks within the NIR-II and NIR-III windows (i.e., 1000 to 1350 nm and 1550 to 1870 nm wavelength ranges, respectively) which can be exploited to obtain photoacoustic images. However, nerve visualization within the NIR-III window is more desirable due to higher lipid absorption peaks and a corresponding valley in the optical absorption of water.

Aim

We present the first known optical absorption cha

SUBMITTER: Graham MT 

PROVIDER: S-EPMC10475953 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature